MARKHAM, ON--(March 7, 2016) - Data presented in a Late Breaking Science session at the 74th Annual Meeting of the American Academy of Dermatology (AAD) in Washington, D.C. demonstrated that calcipotriol/betamethasone dipropionate 50 micrograms/g / 0,5 mg/g) foam formulation is a stable supersaturated solution of the active ingredients.1 The data presented at AAD showed that no calcipotriol or betamethasone dipropionate crystals were identified in the foam spray following application and for up to 18 hours.
- Warren R, et al. Supersaturation of calcipotriene and betamethasone dipropionate – facilitating the improved clinical efficacy of the fixed combination spray foam LEO90100 (calcipotriene 0.005% (Cal) plus betamethasone dipropionate 0.064% (BD)) as compared to other formulations of Cal/BD (abstract)
- Taraska V, et al. Fixed combination aerosol foam calcipotriene 0.005% (Cal) plus betamethasone dipropionate 0.064% (BD) exhibits no impact on the HPA axis and calcium homeostasis in patients with extensive psoriasis vulgaris: a multicenter, single-arm, Phase II, 4-week MUSE study. Presented at the Skin Disease Education Foundation’s 15th Annual Las Vegas Dermatology Seminar & the 11th Annual SDEF Psoriasis Forum, October 30-November 1, 2014
- Parisi R, et al. Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence. The Society for Investigative Dermatology. J Invest Dermatol 2013;133(2):377-85
- Reich K, et al. Efficacy of a fixed combination of with calcipotriol/betamethasone dipropionate topical gel in adult patients with mild to moderate psoriasis: blinded interim analysis of a phase IV, multicentre, randomized, controlled, prospective study. Journal of European Academy of Dermatology Venereology 2014: October (epub ahead of print) DOI: 10.1111/jdv.12774
- Men. ter A, Korman NJ, Elmets CA et alGuidelines of care for the management of psoriasis and psoriatic arthritis. Section 3. Guidelines of care for the manage-ment and treatment of psoriasis with topical therapies. J Am Acad Dermatol 2009;60: 643–659